Quantification of a trace amount of polymorphic impurities is critical especially in the quality control of Active Pharmaceutical Ingredients (APIs). Conventional quantitative analysis by X-ray diffraction (XRD) requires calibration curve preparation, reference intensity ratio (RIR) or crystal structure (Crystallographic Information File, CIF). However, the materials of APIs are often missing from the database. Therefore, their quantification is not straightforward. Rigaku have developed a novel quantitative analysis method called “Direct Derivation (DD)” that requires only XRD data and chemical formula(1)- (3). Here, quantitative analysis of trace amounts of the hydrate phase of API is performed using the DD method and the…
Analysis of metallic Tungsten by high-resolution ICP-OES The rapid analysis of traces impurities in refractory metals and alloys is an important part of the quality-control process in the manufacture of these materials. All classical atomic spectrometry techniques, however, have major disadvantages with respect to trace detectability in these matrices, which for example arise from the high atomization temperatures (AAS), the wealth of emission lines (ICP-OES) and adverse metal oxide formation (ICP-MS) of refractory elements like W, Mo, Ta and Nb. The novel high-resolution array technology of the PlasmaQuant® PQ 9000 eliminates almost all spectral interferences of classical ICP-OES providing increased…
Thanks to its peculiar properties like corrosion, chemical resistance, electrical conductivity and ductility, gold is widely used in electronics industry as material for electrical connections in mass manufactured electronic devices such as circuit boards, integrated chips and semiconductors but also in a variety of novel microelectronic devices like sensors. The well-known biocompatibility of gold has led to its medical use since ancient times. Also a large variety of new applications in high-tech areas, like nanomaterials, are becoming increasingly important. High purity gold (> 99.999 %) is indispensable, since even the smallest contaminants can affect the manufacturing processes as well as the…